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POLYMYXIN B
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DeCS
Descriptor
English
:
Polymyxin B
Descriptor
Spanish
:
Polimixina B
Descriptor
Portuguese
:
Polimixina B
Synonyms
English
:
Aerosporin
Polymyxin B Sulfate
Tree Number:
D04.345.566.780.750
D10.477.750.750
D12.644.050.600.750
D12.644.641.780.750
D12.776.543.695.054.600.750
Definition
English
:
A mixture of
polymyxins
B1 and B2, obtained from
BACILLUS POLYMYXA
strains. They are basic
polypeptides
of about eight
amino acids
and have cationic detergent action on cell
membranes
.
Polymyxin B
is used for treatment of
infections
with
gram-negative bacteria
, but may be neurotoxic and nephrotoxic.
Pharmacological Action:
Anti-Bacterial Agents
History Note
English
:
1991(1978); was see under POLYMYXINS 1978-90; was AEROSPORIN see under POLYMYXIN 1971-77, see POLYMYXIN 1963-70; AEROSPORIN was see POLYMYXIN B 1978-93
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
11549
Unique Identifier:
D011112
Occurrence in VHL
:
Similar:
DeCS